Cushing's syndrome with mediastinal lipomatosis.

نویسندگان

  • Pinaki Dutta
  • Anil Bhansali
  • Somashekara Reddy-KS
  • Shariq R Masoodi
چکیده

ediastinal lipomatosis is a rare benign condition characterized by deposition of a large amount of mature adipose tissue within the mediastinum. The common etiologies are obesity, exogenous or endogenous Cushing’s syndrome, alcohol abuse and rarely it can be idiopathic.1 It is more common now than thought previously, as imaging modalities like computerized tomography (CT) and magnetic resonance imaging (MRI) decisively diagnose this condition. Imaging features include smooth bilateral widening of the superior mediastinum with relative lucency and no definable mass in the lateral x-ray. It is usually asymptomatic, but may sometimes present with compressive symptoms, and often poses a diagnostic dilemma. A 27-year-old male was admitted with excessive weight gain, typical purple striae on the abdomen, generalized increased pigmentation, proximal muscle weakness and psychotic behavior. He had no history of steroid abuse. On examination, he had centripetal obesity, buffalo hump, broad purple striae on the abdomen, pulp atrophy and generalized increased pigmentation. He was hypertensive with blood pressure of 190/110 mm Hg. Biochemical parameters were: serum sodium 135 meq/L; potassium 2.7 meq/L; fasting blood glucose 294 mg/dl; 0800h cortisol, 1000 nmol/L; 2100h cortisol, 640 nmol/L; and adrenocorticotrophic hormone at 2100h 138 pg/ml. Cortisol levels after overnight in low dose and high dose dexamethasone suppression were 520, 960 nmol/L and 780 nmol/L; suggestive M

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Symptomatic epidural lipomatosis in ectopic Cushing's syndrome.

We report a case of spinal epidural lipomatosis (SEL) caused by ectopic Cushing's syndrome and give a review of the literature. The most common cause of SEL is prolonged therapy with glucocorticoids, only a very few cases are related to endogenous Cushing's syndrome. The pathophysiological mechanism is not clear but there is a possible role for the autonomic nervous system in the stimulation of...

متن کامل

Spontaneous hemomediastinum complicating steroid-induced mediastinal lipomatosis.

Spontaneous hemomediastinum is a rare event, occurring in association with bleeding disorders, intratumoral bleeding, or following an abrupt increase in intrathoracic pressure. We report the case of a patient with systemic lupus erythematosus, nephrotic syndrome, and renal failure, in whom mediastinal lipomatosis (ML) developed following increased corticosteroid therapy. Anticoagulant therapy l...

متن کامل

Corticosteroid-Induced Multifocal and Extensive Lipomatosis: A Case Report

Introduction: Corticosteroid-induced lipomatosis are uncommon situation. We report a case of an extensive lipomatosis in a rheumatoid arthritis patient, who received a long term steroid therapy. Case report: A 49-year-old rheumatoid arthritis woman, who received for two years a mean dose of 15 mg/ day of prednisone equivalent, was admitted to the hospital for a six months history of progressive...

متن کامل

CT to the rescue in benign, symmetrical mediastinal lipomatosis.

A 34-year-old woman presented to the chest physician with progressively increasing shortness of breath. She was non-diabetic, non-hypertensive, non-obese without any other co-morbid illnesses. There was no history of prolonged drug intake of any sort. Other associated diseases like Cushing’s syndrome were excluded. A chest radiograph (postero-anterior view) revealed a veil-like opacity in the m...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Saudi medical journal

دوره 25 8  شماره 

صفحات  -

تاریخ انتشار 2004